zf-CXXC: CXXC zinc finger domain
| PAG Title | zf-CXXC: CXXC zinc finger domain |
| PAG ID | PEX002086 |
| Type | A |
| Source Link |  Pfam |
| Publication Reference | NA |
| PAG Description | This domain contains eight conserved cysteine residues that bind to two zinc ions. The CXXC domain is found in a variety of chromatin-associated proteins. This domain binds to nonmethyl-CpG dinucleotides. The domain is characterised by two repeats 3, and shows a peculiar internal duplication in which the second unit is inserted into the first one 4. Each of these units is characterised by four conserved cysteines, displaying a CXXCXXCX(n)C motif that chelate a Zn+2 ion. The DNA binding interface has been identified by NMR 3. In eukaryotes, the CXXC domain is found in stramenopiles, plants and metazoans. Plants possess a mono-CXXC domain that is present in distinct chromatin proteins 4. Structural comparisons show that the mono-CXXC is homologous to the structural-zinc binding domain of medium chain dehydrogenases 4. |
| Species | Homo sapiens |
| nCoCo Score | 0 |
| Base PAG ID | PEX002086 |
| Human Phenotyte Annotation | |
| Curator | PAGER curation team |
| Curator Contact | PAGER-contact@googlegroups.com |
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